This paper tried to explore the mechanism of target gene therapy for oral squamous cell carcinoma by using network pharmacology and Macromolecular docking technology.Literature mining was conducted us-ing databases such as TCMSP,PubChem,Gene Cards,David,STRING 11.5,Swiss Target Prediction,and CNKI to obtain active ingredients and disease-related targets of traditional Chinese medicine,and conditional screening was performed on them.Cytoscape 3.7.2 was utilized for constructing the"drug active ingredient target disease"network diagram of Baiyaozi.Venny 2.1.0 website was used to draw the Venn diagram of the intersection target of Baiyaozi active ingredient oral squamous cell carcinoma.STRING 11.5 website was employed to set the confi-dence level to 0.400 while other settings remained default,and the intersection genes were extracted to make the protein interaction(PPI)relationship network diagram,and core targets were screened according to the relation-ship.The core target interaction network model of"TCM-component-target-disease"was developed.Functional analysis and pathway enrichment analysis were performed based on the David database,and then the bioinformat-ics website(http://www.bioinformatics.com.cn/)was used for conducting visual analysis.As a result,25 active in-gredients of Baiyao seed were obtained and 6 active ingredients were screened.155 effective gene targets were screened and 3450 oral squamous cell carcinoma related gene targets were screened.90 related intersection tar-gets were obtained,and 20 main KEGG pathways were obtained.It is concluded that through network pharmacol-ogy research and analysis,an interaction network of"compounds,targets,and pathways"for the treatment of oral squamous cell carcinoma was constructed to provide a theoretical basis for studying the clinical application of Baiyaozi in the treatment of oral squamous cell carcinoma.
维普
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