Efficient Methyl Esterification of o-chlormandelic Acid under Mild Reaction Conditions
Methyl o-chloromandelic is an important intermediate for the synthesis of clopidogrel,which is ob-tained by esterification reaction under the conditions of sulfuric acid and reflux temperature using o-chloroman-delic acid as the starting material.In this paper,relatively mild boric acid was used as a catalyst to catalyze the es-terification of o-chloromandelic acid and methanol at room temperature.The product was confirmed by FT-IR,1H NMR,13C NMR and HRMS spectra.The effects of catalyst dosage,feed ratio,temperature,and reaction time on the reaction were explored.According to the characteristics of the reaction,the reaction device is im-proved to achieve continuous preparation process for methyl o-chloromandelate.
万方数据
维普
