Simulation Study on Rules of DNA Strand Breakage Damage Caused by Lunar Radiation Environment
The absence of magnetic field and protective atmosphere on the lunar surface results in an extremely harsh radiation environment which poses a significant threat to the health of lunar astro-nauts.In this article,Geant4-DNA simulation software based on the Monte Carlo method was uti-lized to investigate the patterns of DNA strand break damage within cell nuclei under three different space radiation conditions:unshielded lunar surface,astronaut suit shielding,and lunar base shiel-ding.The simulation results indicated that:The proportion of double-strand breaks caused by pro-tons was lower than that caused by iron ions;In the unshielded condition,in the event of a solar particle event,the DNA structure experienced severe damage within a short period,with a total of over 2 million strand breaks,accounting for approximately 0.039%of the total number of base pairs within the cell nucleus;In the galactic cosmic ray environment,radiation risks were primarily driven by long-term cumulative doses.Protons,with their higher flux,exhibited a stronger DNA damaging effect compared to iron ions;However,under shielded conditions,the damage to the DNA structure was significantly reduced,especially in extreme situations such as solar particle events,where up to 99.96%of strand breaks could be mitigated.
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