首页|面向空间细胞培养用多路切换陶瓷阀仿真优化研究

面向空间细胞培养用多路切换陶瓷阀仿真优化研究

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为了满足空间站环境细胞长期自动培养的需求,研制一款新型细胞自动培养装置,装置由微量泵、多路切换阀等组成.通过设计一款多路切换陶瓷阀,实现仅由一组泵阀自由切换多条液路.通过有限元仿真分析培养液、消化液和裂解液 3 种液体在多路切换阀内的压力、温度、流速等物理参数分布情况,确定最佳阀位布局,并优化阀体结构,以改善不同液体流入阀腔后分布均匀性.优化后多路切换阀内细胞培养液和消化液的压力和温度分布波动率均小于1%,流速稳定.裂解液温度分布变化在优化前为2℃,优化后小于0.01℃.液体流动更加顺畅,滞留现象减少.仿真结果表明:优化后的陶瓷阀有助于提升空间细胞培养的稳定性和经济性.
Study on Structure Design and Optimization of Multi-channel Switching Ceramic Valve for Space Cell Culture
In order to meet the demand of long-term automatic cell culture in space station environ-ment,a new type of automatic cell culture device was developed.It was mainly composed of micro-pump and multi-channel switching valve.By designing a multi-channel switching ceramic valve,multiple liquid paths could be freely switched by only one pump and valve.Through finite element simulation analysis on the distribution of physical parameters such as pressure,temperature,and flow rate of three liquids,namely culture solution,digestion solution,and cracking solution,in the multi-channel switching valve,the optimal valve layout was determined and the valve body structure was optimized which improved the uniformity of distribution of different liquids after flowing into the valve chamber.After optimization,the pressure and temperature fluctuation rates of the cell culture medium and digestion medium in the multi-channel switching valve were both less than 1%,and the flow rate was stable.The temperature distribution variation of the cracking solution was 2℃before optimization,but less than 0.01℃after optimization,resulting in smoother liquid flow and reduced retention phenomenon.The simulation results showed that the optimized ceramic valve can help to improve the stability and economy of space cell culture.

space cell culturemulti-way switching valvecomputational fluid dynamicsfinite ele-ment analysisceramic valve

郭淼、谭映军、陈博博、施镠佳、李芳、王春艳、李越、聂捷琳、刘仲馨、李莹辉

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北京信息科技大学自动化学院,北京 100192

中国航天员科研训练中心航天医学全国重点实验室,北京 100094

北京来普惠康医学技术有限公司,北京 101300

空间细胞培养 多路切换阀 计算流体力学 有限元分析 陶瓷阀

航天医学全国重点实验室基金项目

SMFA22B03

2024

载人航天
中国载人航天工程办公室

载人航天

CSTPCD北大核心
影响因子:0.411
ISSN:1674-5825
年,卷(期):2024.30(4)
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