Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable attention.In this study,TME-activatable 3,3',5,5'-tetramethylbenzidine(TMB)-copper peroxide(CuO2)@poly(lactic-co-gly colic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO2 NPs and TMB into PLGA camouflaged by RBCMs.As an efficient H2O2 sup-plier,once exposed to a proton-rich TME,CuO2 NPs can generate H2O2 and Cu2+,which are further reduced to Cu+by endogenous glutathione.Subsequently,the Cu+-mediated Fenton-like reaction produces cytotoxic-OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal effects.Combined with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.
Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM),School of Physical and Mathematical Sciences,Nanjing Tech University(NanjingTech),Nanjing 211816,China
School of Physical Science and Information Technology,Liaocheng University,Liaocheng 252059,China
Department of Hepatobiliary and Pancreatic Surgery,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China
School of Chemical and Biomedical Engineering,Lee Kong Chian School of Medicine,Nanyang Technological University,62 Nanyang Drive,Singapore 637459,Singapore
展开 >
国家自然科学基金国家自然科学基金国家自然科学基金国家自然科学基金Jiangsu Province Policy Guidance PlanJiangsu Provincial key research and development plan山东省自然科学基金Taishan scholars construction special fund of Shandong Province宁波市自然科学基金Jiangsu postgraduate research innovation program
NETL
NSTL
万方数据
