Abstract
Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable attention.In this study,TME-activatable 3,3',5,5'-tetramethylbenzidine(TMB)-copper peroxide(CuO2)@poly(lactic-co-gly colic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO2 NPs and TMB into PLGA camouflaged by RBCMs.As an efficient H2O2 sup-plier,once exposed to a proton-rich TME,CuO2 NPs can generate H2O2 and Cu2+,which are further reduced to Cu+by endogenous glutathione.Subsequently,the Cu+-mediated Fenton-like reaction produces cytotoxic-OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal effects.Combined with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.
基金项目
国家自然科学基金(62120106002)
国家自然科学基金(51803091)
国家自然科学基金(61935004)
国家自然科学基金(22175089)
Jiangsu Province Policy Guidance Plan(BZ2019014)
Jiangsu Provincial key research and development plan(BE2021711)
山东省自然科学基金(ZR2020KB018)
Taishan scholars construction special fund of Shandong Province()
宁波市自然科学基金(202003N40448)
Jiangsu postgraduate research innovation program(KYCX21_1103)
NETL
NSTL
万方数据