Abstract
The pancreas exerts endocrine and exocrine functions in energy balance.The neural innervation and immune mi-lieu are both crucial in supporting pancreatic homeostasis.The neuronal network connects the pancreas with the central nervous system(CNS)and the enteric nervous system(ENS)and sustains metabolic activities.The nerves in the pancreas are categorized as spinal sensory afferent fibers,vagal sensory afferent nerves,autonomic fibers of both sympathetic and parasympathetic divisions,and fibers from the ENS and intrapancreatic ganglia.They innervate different regions and various cell types,which collectively determine physiological functions.Studies have established that the diverse pathological conditions,including pancreatitis,diabetes,and pancreatic tumor,are attributed to aberrant immune reactions;however,it is largely not clear how the neuronal network may influence the disease conditions.Enlightened by the recent advances illuminating the organ-wide neuronal archi-tecture and the dysfunctions in pancreatic disorders,this review will highlight emerging opportunities to explore the cellular interrelationship,particularly the neuroimmune components in pancreatic health and diseases.
基金项目
国家自然科学基金(32225019)
国家自然科学基金(32394003 31822018)
国家自然科学基金(31770936)
国家重点研发计划(2023YFC2306300)
北京市自然科学基金(5222010)
Tsinghua University(School of Medicine)-Xiamen Changgeng Hospital Co Ltd Joint Research Center for Anaphylactic Disease()
Center for Life Sciences,the Institute for Immunology()
School of Medicine at Tsinghua University()
NETL
NSTL
万方数据