首页|The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases
The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases
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According to a study from World Health Organization's Global Burden of Disease,mental and neurological disor-ders have accounted for 13％ of global diseases in recent years and are on the rise.Neuropsychiatric conditions or neuroinflammatory disorders are linked by the presence of an exaggerated immune response both peripherally and in the central nervous system(CNS).Cognitive dysfunction(CD)encompasses a complex group of diseases and has frequently been described in the field of autoimmune diseases,especially in multiple non-CNS-related autoimmune diseases.Recent studies have provided various hypotheses regarding the occurrence of cognitive impairment in autoimmune diseases,including that abnormally activated immune cells can disrupt the integrity of the blood-brain barrier(BBB)to trigger a central neuroinflammatory response.When the BBB is intact,au-toantibodies and pro-inflammatory molecules in peripheral circulation can enter the brain to activate microglia,inducing CNS inflammation and CD.However,the mechanisms explaining the association between the immune system and neural function and their contribution to diseases are uncertain.In this review,we used clinical statistics to illustrate the correlation between CD and autoimmune diseases that do not directly affect the CNS,summarized the clinical features and mechanisms by which autoimmune diseases trigger cognitive impairment,and explored existing knowledge regarding the link between CD and autoimmune diseases from the perspective of the field of neuroimmunology.
Autoimmune diseasesNeuroinflammationCentral nervous system dysfunctionAutoantibodiesInflammatory cytokines
Ke-qi Fan、Tao Huang、Jian-shuai Yu、Yi-yuan Li、Jin Jin
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MOE Laboratory of Biosystem Homeostasis and Protection,and Life Sciences Institute,Zhejiang University,Hangzhou 310058,China
Department of Gastroenterology,Sir Run Shaw Hospital,College of Medicine Zhejiang University,Hangzhou 310016,China
Key Laboratory for Developmental Genes and Human Disease,Ministry of Education,Institute of Life Sciences,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing 210096,China
distinguished Young Scientist Fund of NSFCNational Natural Science Foundation of China,Key Program浙江省自然科学基金浙江省自然科学基金国家重点研发计划国家自然科学基金高等学校学科创新引智计划(111计划)
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