Allogenic microglia replacement:A novel therapeutic strategy for neurological disorders

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外文摘要：Microglia are resident immune cells in the central nervous system(CNS)that play vital roles in CNS development,homeostasis and disease pathogenesis.Genetic defects in microglia lead to microglial dysfunction,which in turn leads to neurological disorders.The correction of the specific genetic defects in microglia in these disorders can lead to therapeutic effects.Traditional genetic defect correction approaches are dependent on viral vector-based genetic defect corrections.However,the viruses used in these approaches,including adeno-associated viruses,lentiviruses and retroviruses,do not primarily target microglia;therefore,viral vector-based genetic defect corrections are ineffective in microglia.Microglia replacement is a novel approach to correct microglial genetic defects via replacing microglia of genetic defects with allogenic healthy microglia.In this paper,we systematically review the history,rationale and therapeutic perspectives of microglia replacement,which would be a novel strategy for treating CNS disorders.

外文关键词：

MicrogliaReplacementMicroglia replacementMicroglia depletionMicroglia-free nicheCSF1R

作者：

Yanxia Rao、Bo Peng

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作者单位：

Department of Laboratory Animal Science,MOE Frontiers Center for Brain Science,Fudan University,Shanghai 200032,China

Department of Neurosurgery,Huashan Hospital,Institute for Translational Brain Research,State Key Laboratory of Medical Neurobiology,MOE Frontiers Center for Brain Science,MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases,Fudan University,Shanghai 200000,China

Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu 226001,China

基金：

STI2030-Major ProjectsSTI2030-Major Projects国家自然科学基金国家自然科学基金Program of Shanghai Academic/Technology Research LeaderShanghai Pilot Program for Basic ResearchShuguang Program from Shanghai Education Development Foundation and Shanghai Municipal Education CommissionShanghai Municipal Science and Technology Major ProjectInnovative Research Team of High-Level Local University in Shanghai

项目编号：

2022ZD02047002022ZD0207200321709583200067821XD142040021TQ01422SG07

出版年：

2024

DOI：

10.1016/j.fmre.2023.02.025

自然科学基础研究(英文)

CSTPCD

ISSN：

年,卷(期)：2024.(2)

参考文献量176