首页|Skull and vertebral bone marrow in central nervous system inflammation
Skull and vertebral bone marrow in central nervous system inflammation
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Emerging evidence has highlighted the capacity of hematogenous cells in skull and vertebral bone marrow to enter the meningeal borders via ossified vascular channels and maintain immune homeostasis in the central nervous system(CNS).CNS-adjacent skull and vertebral bone marrow comprises hematopoietic niches that can sense CNS injury and supply specialized immune cells to fine-tune inflammatory responses.Here,we review recent advances in our understanding of skull and vertebral bone marrow-derived immune cells in homeostasis and inflammatory CNS diseases.Further,we discuss the implications for future development of therapies to mitigate CNS inflammation and its detrimental sequelae in neurological disorders.
Central nervous systemBone marrowHematopoiesisImmune cellsNeuroinflammationStrokeMultiple sclerosis
Honglei Ren、Qiang Liu
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Department of Neurology,Tianjin Neurological Institute,Tianjin Institute of Immunology,State Key Laboratory of Experimental Hematology,International Joint Laboratory of Ocular Diseases,Ministry of Education,Haihe Laboratory of Cell Ecosystem,Tianjin Medical University General Hospital,Tianjin 300052,China
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