首页|Neuroimmune interactions and their roles in neurodegenerative diseases
Neuroimmune interactions and their roles in neurodegenerative diseases
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The nervous system possesses bidirectional,sophisticated and delicate communications with the immune system.These neuroimmune interactions play a vitally important role in the initiation and development of many disorders,especially neurodegenerative diseases.Although scientific advancements have made tremendous progress in this field during the last few years,neuroimmune communications are still far from being elucidated.By organizing recent research,in this review,we discuss the local and intersystem neuroimmune interactions and their roles in Alzheimer's disease,Parkinson's disease and amyotrophic lateral sclerosis.Unveiling these will help us gain a better understanding of the process of interplay inside the body and how the organism maintains homeostasis.It will also facilitate a view of the diseases from a holistic,pluralistic and interconnected perspective,thus providing a basis of developing novel and effective methods to diagnose,intervene and treat diseases.
Neuroscience Research Institute and Department of Neurobiology,School of Basic Medical Sciences,Key Laboratory for Neuroscience,Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs,Peking University,Beijing 100083,China
PKU-IDG/McGovern Institute for Brain Research,Peking University,Beijing 100871,China
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