首页|Fibroblasts:New players in the central nervous system?

Fibroblasts:New players in the central nervous system?

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Fibroblasts are typically described as cells that produce extracellular matrix,contribute to the formation of con-nective tissue,and maintain the structural framework of tissues.Fibroblasts are the first cell type to be transdif-ferentiated into inducible pluripotent stem cells(iPSCs),demonstrating their versatility and reprogrammability.Currently,there is relatively extensive characterization of the anatomical,molecular,and functional diversity of fibroblasts in different peripheral organs and tissues.With recent advances in single cell RNA sequencing,heterogeneity and diversity of fibroblasts in the central nervous system(CNS)have also begun to emerge.Based on their distinct anatomical locations in the meninges,perivascular space,and choroid plexus,as well as their molecular diversity,important roles for fibroblasts in the CNS have been proposed.Here,we draw inspirations from what is known about fibroblasts in peripheral tissues,in combination with their currently identified CNS locations and molecular characterizations,to propose potential functions of CNS fibroblasts in health and disease.Future studies,using a combination of technologies,will be needed to determine the bona fide in vivo functions of fibroblasts in the CNS.

FibroblastsCentral nervous systemInfectionAgingNeurodegenerative diseasesInjury

Lihui Duan、Xiang Yu

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State Key Laboratory of Molecular Development Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 100049,China

State Key Laboratory of Membrane Biology,School of Life Sciences,Peking University,Beijing 100871,China

Peking-Tsinghua Center for Life Sciences and Peking University McGovern Institute,Peking University,Beijing 100871,China

Chinese Institute for Brain Research,Beijing 102206,China

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国家自然科学基金科技部项目

320300492021ZD0202500

2024

10.1016/j.fmre.2023.01.014

自然科学基础研究(英文)

自然科学基础研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.(2)
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