Abstract
Glioblastoma(GBM)causes nearly universal mortality as a result of the failure of conventional therapies includ-ing surgical resection,targeted radiation therapy,and chemotherapy.An increasingly important treatment option is combining immunotherapy with other therapies in both preclinical and clinical studies.The central nervous system(CNS)has been historically considered an immune privileged area,but increasing evidence,including the recent rediscovery of meningeal lymphatic vessels(MLVs),has overturned this notion.MLVs are populated by multiple immune cells and connect the CNS to the periphery by draining cerebrospinal fluid with soluble CNS antigens and immune cells into cervical lymph nodes.In the past few years,more and more studies have indicated that MLVs are involved in the regulation of inflammation and the immune response in the pathogenesis of var-ious CNS diseases including GBM.Here,we explore the critical interlinkages between MLVs and GBM therapies including chemotherapy,radiotherapy and immunotherapy,and propose the meningeal lymphatic vasculature as a general target for GBM therapy.
基金项目
国家自然科学基金(81930011)
国家自然科学基金(91739304)
国家自然科学基金(31821091)
国家重点研发计划(2019YFA0801603)
Peking-Tsinghua Center for Life Sciences()
中国博士后科学基金(2022T150012)
NETL
NSTL
万方数据