甘油三酯-葡萄糖乘积指数与女性非糖尿病高血压左心室肥厚的相关性探讨
Correlation between triglyceride-glucose index and left ventricular hypertrophy in female non-diabet-ic patients with hypertension
陆美杉 1李宪伦 2张仕宇 3姜红2
作者信息
- 1. 北京中医药大学 中日友好临床医学院,北京 100029
- 2. 中日友好医院 中西医结合心脏内科,北京 100029
- 3. 中日友好医院心脏科,北京 100029
- 折叠
摘要
目的:探讨女性非糖尿病高血压患者甘油三酯-葡萄糖乘积(TyG)指数与左心室肥厚(LVH)的相关性.方法:回顾分析133名女性非糖尿病高血压患者,采用Pearson相关性分析与左室质量指数(LVMI)相关的因素,通过二元logistic回归分析获得LVH的影响因素,并通过ROC曲线分析TyG指数预测LVH的最佳截断值以及灵敏度和特异度.结果:在女性非糖尿病高血压患者中,与TyG指数低值组比较,TyG指数高值组其LVMI也较高.Pearson相关性分析发现LVMI与TyG指数、收缩压及夜间舒张压呈正相关(P＜0.05).二元Logistic回归分析显示,TyG 指数和夜间收缩压是 LVH 的预测因素(OR=3.486,95％CI:1.417～8.577;OR=1.048,95％CI:1.019～1.077).TyG指数与夜间收缩压联合预测LVH的AUC为0.75(95％CI:0.659～0.847),灵敏度为64.7％,特异度为76.8％.结论:在女性非糖尿病高血压患者中,TyG指数和夜间收缩压与左室质量指数呈正相关,可以作为左心室肥厚的预测因子.
Abstract
Objective:To discuss the correlation between triglyceride-glucose(TyG)index and left ventricular hypertrophy(LVH)in female non-diabetic hypertensive patients.Methods:A total of 133 female non-diabetic hypertensive patients were included in this retrospective study.Pearson correlation analysis was performed to analyze factors related to left ventricular mass index(LVMI),and the influencing factors of LVH were ob-tained by binary logistic regression analysis.ROC curve was used to analyze the cut-off value,sensitivity and specificity of TyG index predicting LVH.Results:In female non-diabetic hypertensive patients,LVMI was high-er in the group with high TyG index,compared with the group with low TyG index.Pearson correlation analy-sis showed that LVMI was positively correlated with TyG index,systolic blood pressure and nocturnal diastol-ic blood pressure(P＜0.05).Binary logistic regression analysis showed that TyG index and nocturnal systolic blood pressure were predictors of LVH(OR=3.486,95％CI:1.417～8.577;OR=1.048,95％CI:1.019～1.077).The AUC of TyG index combined with nocturnal systolic blood pressure predicting LVH was 0.75(95％CI:0.659～0.847),the sensitivity was 64.7％,the specificity was 76.8％.Conclusion:In female non-diabetic hypertensive patients,TyG index as well as nocturnal systolic blood pressure were positively correlated with left ventricular mass index,meanwhile,could be used as predictors of left ventricular hypertrophy.
关键词
原发性高血压/甘油三酯葡萄糖乘积指数/胰岛素抵抗/左心室肥厚/左室质量指数/动态血压监测Key words
essential hypertension/triglyceride-glucose index/insulin resistance/left ventricular hypertrophy/left ventricular mass index/ambulatory blood pressure monitoring引用本文复制引用
基金项目
高水平医院临床业务费专项临床研究项目(2022-NHL-HCRF-LX-02)
出版年
2024
NETL
NSTL
维普
万方数据