The value of ultrasound combinational elastography inflammation activity-related A index in diagnos-ing non-alcoholic steatohepatitis
Objective:To evaluate the diagnostic efficacy of ultrasound combinational elastography A index re-lated to inflammation activity for non-alcoholic steatohepatitis(NASH).Methods:Clinical baseline,combination-al elastography activity-related A index,laboratory tests,and liver histopathological data of inpatients at De-partment of General Surgery&Obesity and Metabolic Disease Center in China-Japan Friendship Hospital were retrospectively analyzed.Clinical characteristics and laboratory tests were compared between the NASH and non-NASH groups.The difference in A index between the NASH and non-NASH groups was analyzed using pathological diagnosis as the gold standard.Receiver operating characteristic curves were plotted to explore the diagnostic efficacy of the A index for NASH.Results:Among the 53 patients included in the study,there were 18 cases in the NASH group and 35 cases in the non-NASH group,with a mean age of 34.8±9.3 years.The mean body mass index(BMI)was 37.0±5.5g/m2,and the A index was 1.00±0.13(range 0.62～1.33).The median of the A index was 1.02,ranging from 0.62 to 1.33.There was a statistically significant differ-ence in the A index between the NASH group and the non-NASH group(P=0.000).The area under the curve(AUC)of the A index for diagnosing NASH was 0.889.When the critical value was 1.035,the sensitivity and specificity of the diagnosis were 0.722 and 0.800,respectively.Conclusion:The combination of elastography and inflammation activity related A-index can effectively distinguish between simple fatty liver and NASH in non-alcoholic fatty liver disease,and has high clinical application value.
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