Objective:To investigate the risk factors for the development of vocal process granulomas associat-ed with laryngopharyngeal reflux disease and evaluate the treatment efficacy of proton pump inhibitors(PPIs).Methods:A total of 120 patients with laryngopharyngeal reflux disease(LPRD)were included in this study.De-tailed basic information and medical histories were collected,including age,gender,body mass index(BMI),and lifestyle such as smoking,alcohol consumption,eating habits near bedtime,chronic cough,and frequent vo-cal strain.We utilized both univariate and multivariate regression analyses to explore the relationships be-tween these factors and vocal process granulomas.Treatment involved an initial course of PPIs for 2-3 months,with subsequent micro-laryngeal laser surgery and extended PPI therapy for non-responders.Patient outcomes were assessed at 2-3 months post-intervention.Results:Through chi-square test and logistic regres-sion analysis,significant correlations were identified between vocal process granulomas associated with laryngo-pharyngeal reflux disease and factors such as gender,BMI,smoking,and alcohol consumption(P＜0.05).Key risk factors include being male,having a BMI greater than 25kg/m2,smoking and drinking.The administration of PPIs was beneficial for the majority of participants.For individuals who did not initially respond to pharma-cological treatment,the sequential approach of micro-laryngeal surgery followed by extended PPI therapy proved to be effective.Conclusion:Gender,BMI,smoking and alcohol consumption are significant influencing factors in the development of vocal process granulomas associated with laryngopharyngeal reflux disease.PPI-based treatment is advisable as a first-line therapy,with surgical intervention reserved for pharmacologically resistant cases.
关键词
咽喉反流性疾病/声带突肉芽肿/危险因素/治疗效果
Key words
laryngopharyngeal reflux disease/vocal process granulomas/risk factors/treatment efficacy
维普
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