Study on the prevention and control efficacy and cost-effectiveness of different detection technologies for drug-resistant tuberculosis
Objective:To assess the efficacy and cost-effectiveness of different diagnostic technologies for drug-resistant tuberculosis.Methods:Based on the incidence and transmission characteristics of drug-resistant tuberculosis,a decision tree-Markov model was constructed to evaluate the number of incident cases,deaths,total medical costs,and health benefits(measured in quality-adjusted life years,QALYs)of drug-resistant tuber-culosis over a 20-year period using different detection methods,including solid culture with drug susceptibili-ty testing,Xpert testing,liquid culture with drug susceptibility(LCDS)testing,and whole-genome sequencing(WGS)technology.Cost-effectiveness analysis was also conducted.Results:Compared to the solid culture and drug susceptibility testing approach,Xpert demonstrated the best performance,with lower numbers of monthly average incident cases,relapse cases,and death during the cycle.Cost-effectiveness analysis showed that,com-pared to solid culture followed by drug susceptibility testing,the other three diagnostic technologies were all cost-effective.The incremental cost-effectiveness ratio(ICUR)for Xpert testing was-2598.89 CNY/QALY,for LCDS testing,it was-2476.66 CNY/QALY,and for WGS,it was-2429.46 CNY/QALY.Conclusion:Compared to the solid culture and drug susceptibility testing approach,Xpert testing,LCDS testing and WGS testing re-duced the number of incident cases and deaths,increased QALYs,and were all cost-effective,with Xpert test-ing being the most cost-effective among them.
万方数据
维普
