The value of ambulatory monitoring of three serological indicators in the early diagnosis of infectious pancreatic necrosis secondary to moderately severe and severe acute pancreatitis
Objective:To investigate the value of dynamic monitoring of interleukin-1β(IL-1β),angiotensin n(AngⅡ)and fibrinogen-like protein 1(FGL-1)in the early prediction of infectious pancreatic necrosis(IPN)secondary to moderately severe acute pancreatitis(MSAP)and severe acute pancreatitis(SAP)patients.Methods:The data of 103 MSAP and SAP patients admitted to the Second Affiliated Hospital of Anhui Medical Uni-versity from January 2022 to June 2023 were collected,including 35 cases with secondary IPN(IPN group)and 68 cases without IPN(control group),and the levels of IL-1β,AngⅡ and FGL-1 on the 1st,4th,and 7th days after admission were dynamically monitored.ROC curve was used to analyze the AUC,sensitivity and specificity,and correlation analysis with modified CT severity index(MCTSI)was performed.Results:The difference in procalcitonin levels and MCTSI on the first day of admission between the two groups was statis-tically significant(P＜0.05).The levels of IL-1β,AngⅡ,and FGL-1 in the IPN group were higher than those in the non-IPN group(P＜0.05),the early IL-1β,Ang Ⅱ,and FGL-1 were positively correlated with the MCTSI(r=0.6205,0.6163,0.7582,P＜0.05).The AUC of the three indexes were 0.698,0.795 and 0.860 for early pre-diction of MSAP and SAP secondary IPN,respectively,and when IL-1β≥6.480pg/ml,Ang Ⅱ ≥16.219ng/ml,and FGL-1≥20.517μg/L were the diagnostic threshold.The sensitivity of the three tests could be increased to 0.997,specificity could be increased to 0.966 when the combination of the three tests were performed in par-allel tests.Conclusion:Dynamic monitoring of serum IL-1β,AngⅡ,and FGL-1 has certain clinical value in the early diagnosis of IPN secondary to MSAP and SAP.
acute pancreatitisinfectious pancreatic necrosisinterleukin-1βangiotensin nfibrinogen-like protein 1
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