Integrin β3 promotes metastasis of nasopharyngeal carcinoma cells by activating the MAPK/ERK pathway
Nasopharyngeal carcinoma(NPC)is a prevalent head and neck malignancy in South China and Southeast Asia,often leading to treatment failure due to distal metastasis and local recurrence.This study showed a significant increase in the expression of integrin β3(ITGB3)in highly metastatic NPC cells compared to poorly metastatic NPC cells.This study further elucidates that upregulation of ITGB3 expression not only enhances the migratory,invasive,clonogenic,and adhesive capacities of NPC cells,but also promotes their proliferation and inhibiting apoptosis.Mechanistically,ITGB3 primarily acti-vates the MAPK/ERK pathway,as a result,enhancing the migratory,invasive,clonogenic,and adhesive capabilities of NPC cells.These findings in the study reveal the regulatory effect and molecular mecha-nism of ITGB3 on NPC cell metastasis,providing a new theoretical basis for the prevention and treat-ment of NPC cell metastasis.
国家科技期刊平台
NSTL
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