The metabolites from mangrove endophytic fungus Talaromyces amestolkiae 30
The metabolites of the endophytic fungus Talaromyces amestolkiae 30 from the mangrove plant Aegiceras corniculatum(L.)Blanco were investigated.The fungus was cultured in rice medium,the monomeric compounds were isolated and purified by the chromatographic technique,and the structures of the compounds were identified by analysis of spectroscopy such as ESIMS and NMR.Twelve known analogues of isocoumarins(1-12)were isolated and identified as aspergillumarin A(1),aspergillumarin B(2),5,6-dihydroxy-3-(4-hydroxypentyl)-isochroman-1-one(3),mucorisocoumarin A(4),peniisocoumarin H(5),peniisocoumarin E(6),dichlorodiaportin(7),mucorisocoumarin C(8),peni-isocoumarin G(9),talumarin A(10),5,6,8-trihydroxy-4-(1'-hydroxyethyl)-isocoumarin(11)and sescan-delin(12).Among them,compounds 4,6 and 7 were obtained from the genus Talaromyces for the first time.The antibacterial activities of these compounds were tested in vitro using the twofold dilution method.Compounds 4,6,and 7 showed inhibitory activity against Staphylococcus aureus.The cytotoxic activity was tested by the MTT assay.Compound 7 showed cytotoxicity against prostate cancer PC-3 cells and VCaP cells.
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