首页|Triple-layered core-shell fiber dressings with enduring platelet conservation and sustained growth factor release abilities for chronic wound healing
Triple-layered core-shell fiber dressings with enduring platelet conservation and sustained growth factor release abilities for chronic wound healing
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NSTL
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Platelet-rich plasma(PRP)is one of the most popular biomaterials in regenerative medicine.However,the difficulties encountered in its preservation,and the requirement for on-demand prepara-tion severely limit its application.In addition,its rapid degrada-tion in the wound microenvironment makes the sustained release of growth factors impossible and finally reduces the therapeutic effect on chronic wounds.Here,a multifunctional dressing based on triple-layered core-shell fibers for loading and enduring preservation of PRP was developed using a one-step co-axial bioprinting technique combined with freeze-drying.The platelets were effectively dispersed and immobilized in the core layer of the fiber,leading to a sustained release of growth factors from the PRP.The rate of release can be controlled by adjusting the triple-layered core-shell structure.Simultaneously,the triple-layered core-shell structure can reduce the deactivation of PRP during freezing and storage.The experimental findings suggest that PRP exhibits sustained activity,facilitating the process of wound healing even after a storage period of 180 days.Furthermore,the protective mechanism of PRP by the triple-layered core-shell fiber was investigated,and the conditions for freeze-drying and storage were opti-mized,further enhancing the long-term storability of PRP.As a result,the multifunctional core-shell fiber dressings developed in this study offer a novel approach for sustained growth factor release and the enduring preservation of active PRP.
NETL
NSTL
万方数据
