The effect of Miao medicine Periploca forrestii on the number of Th22 cells and the expression levels of IL-17,IL-22,and IL-35 in CIA rats
Objective To observe the effects of Miao medicine Periploca forrestii on the number of Th22 cells and the expression levels of IL-17,IL-22,and IL-35 in CIA rats.Methods Sixty CIA rats were randomLy divided into normal control group,model control group,positive control group(Tripterygium wilfordii glycosides tablets,9.45 mg/kg),Periploca forrestii low-dose group(22 mg/kg),medium-dose group(44 mg/kg),and high-dose group(67 mg/kg),with 10 rats in each group.The CIA model in rats was established and given medication for 21 consecutive days.The serum levels of IL-17,IL-22,and IL-35 and the number of Th22 cells were measured,and the performance of foot tissue under microscopy was observed.Results Compared with the model control group,the positive control group,Periploca forrestii low-dose group,medium-dose group,and high-dose group showed a significant decrease in the levels of IL-17,IL-22,and the proportion of Th22 cells,while the level of IL-35 in serum significantly increased.The high-dose group of Periploca forrestii was superior to the positive control group in reducing the levels of IL-17,IL-22 in serum and increasing the level of IL-35.Conclusion Periploca forrestii can reduce the number of Th22 cells,regulate the expression of cytokines such as IL-17,IL-22,and IL-35,play a role in reducing the activation and infiltration of inflammatory cells,inhibiting joint inflammation,thereby slowing down the progression of RA.
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