Understanding the dynamic spatiotemporal changes in suitable cultivation areas for Panax notoginseng in Yunnan province amid climate change is crucial for guiding its introduction,cultivation,and large-scale industrial development.Util-izing 131 geographical distribution data points of Panax notoginseng in Yunnan province and 15 environmental variables,we employed the MaxEnt model to analyze the primary factors influencing its distribution and to delineate the suitable cultivation areas and their variations from 1961 to 2020.Our analysis identified key factors,including mean daily temperature range(<10.0℃),the number of days with maximum temperature ≥ 33℃(<5 days),aspect(north-facing slopes),annual accumula-tion temperature ≥ 10℃(4708.0-5331.9 ℃ d),annual sunshine duration(1636.7-1963.3 h),and seasonal variation in precipi-tation(92%-96%).Suitable cultivation areas for Panax notoginseng were primarily concentrated in southeastern Yunnan Province,encompassing Wenshan,Honghe,Kunming,Yuxi,and Qujing,comprising approximately 4.8%of the entire prov-ince.Our findings indicate that climate change from 1961 to 2020 has led to an 18.1%expansion in suitable areas for Panax notoginseng cultivation across Yunnan province.Moreover,over the past six decades,there has been a noticeable northward expansion of the optimal boundary for Panax notoginseng,accompanied by an overall improvement in its suitability amid climate fluctuations.This study provides a theoretical framework and technical support for devising a rational industrial layout for Panax notoginseng in Yunnan province,thereby mitigating the potential risks posed by climate change to its production and facilitating the effective management and utilization of agricultural land resources.