为评价氯氟醚菌唑在黄瓜中残留产生的膳食摄入风险,于2017年-2018年进行了 2年12地规范残留试验,建立了黄瓜中氯氟醚菌唑的超高效液相色谱-串联质谱(UPLC-MS/MS)分析检测方法,并对我国一般人群进行了膳食摄入风险评估.样品经乙腈提取,C18净化,UPLC-MS/MS检测,外标法定量.结果表明:在0.01～1 mg/kg添加水平下,氯氟醚菌唑的平均回收率为90％～108％,相对标准偏差(relative standard deviation,RSD)为3％～12％,定量限(limit of quantification,LOQ)为0.01 mg/kg.400 g/L氯氟醚菌唑悬浮剂按有效成分150 g/hm2施药3次,于末次施药后1、3、5 d采样测定,黄瓜中氯氟醚菌唑残留量为＜0.01～0.64 mg/kg.膳食摄入风险评价结果显示:我国一般人群的氯氟醚菌唑国家估计每日摄入量(national estimates of daily intake,NEDI)为0.217 0 mg,风险商(risk quo-tient,RQ)为 6.9％,表明氯氟醚菌唑在黄瓜中残留不会对一般人群健康造成不可接受的风险.
Residue and dietary risk assessment of mefentrifluconazole in cucumber
In order to evaluate dietary intake risk of mefentrifluconazole residues in cucumber,the residual trial of mefentrifluconazole in cucumber were carried out in 12 places for two years in 2017 and 2018,respectively.An analytical method for residue determination of mefentrifluconazole in cucumber was developed by ultra performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS).The dietary intake risk assessment to general population was investigated.The samples were extracted by acetonitrile,purified by C18,detected by UPLC-MS/MS,and quantified by external standard method.The results showed that the average recoveries of mefentrifluconazole ranged from 90％to 108％with relative standard deviations(RSD)of 3％to 12％,and the limit of quantification(LOQ)in cucumber was 0.01 mg/kg at 0.01-1 mg/kg spiked level.Mefentrifluconazole suspension of 400 g/L was applied three times with active ingredient 150 g/hm2.The residue of mefentrifluconazole in cucumber was＜0.01-0.64 mg/kg 1,3 and 5 days after the last application.Dietary intake risk assessment showed that the national estimated daily intake(NEDI)of mefentrifluconazole was 0.217 0 mg for the general population,and the risk quotient(RQ)was 6.9％,which demonstrated that the terminal residue of mefentrifluconazole in cucumber would not cause unacceptable risk to the health of the general population.
万方数据
维普
