Research progress on cytochrome P450-mediated weed resistance
Cytochrome P450(P450)is an important superfamily of heme-thiolate proteins and belongs to the monooxygenase class,widely distributed throughout the biological realm.Studies have shown that plant P450s mainly serve two functions:"biosynthesis"and"biodegradation",and are known as the"universal biocatalyst".Notably,the initial detoxification of most herbicides in plants relies on the activity of cytochrome P450.In recent years,the prevalence of herbicide-resistant weeds mediated by P450s has escalated,showcasing a complex resistance spectrum and posing new challenges to agricultural production.This article undertakes a comprehensive review encompassing the classification and nomenclature of plant P450s,the interplay between P450s and herbicide metabolism,methodologies for identifying P450-mediated resistance,species of P450-mediated herbicide resistant weeds,and the cloning of plant cytochrome P450 genes related to herbicide metabolism.Our aim is to provide a valuable reference for the related research in this field.
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