Abstract
The Sui people living in Guizhou province have a unique ethnic culture and population history due to their long-time isolation from other populations.To investigate the genetic structure of Sui populations in different regions of Guizhou,we genotyped 89 individuals from four Sui populations using genome-wide single nucleotide polymorphisms arrays.We analyzed the data using principal component analysis,ADMIXTURE analysis,f-statistics,qpWave/qpAdm,TreeMix analysis,fineSTRUCTURE,and GLOBETROTTER.We found that Sui populations in Guizhou were genetically homogeneous and had a close genetic affinity with Tai-Kadai-speaking populations,Hmong-Mien-speaking Hmong,and some ancient populations from southern China.The Sui populations could be modeled as an admixture of 33.5%-37.9%of Yellow River Basin farmer-related ancestry and 62.1%-66.5%of Southeast Asian-related ancestry,indicating that the southward expansion of northern East Asian-related ancestry influenced the formation of the Tai-Kadai-speaking Sui people.Future publications of more ancient genomics in southern China could effectively provide further insight into the demographic history and population structure of the Sui people.