Objective Assess the curative effect of CAPRI cells in the treatment of chronic hepatitis B patients, and explore its impact on T cellsubsets to further find the underlying mechanism of CAPRI cells. Methods With the informed consent of 6 patients, each patient was given one period of treatment with CAPRI cells. Routine examination of blood, liver function and the load of hepatitis B virus, as wel as T cellsubsets were performed before treatment and four weeks after treatment. Results ALT (p<0.05) and HBV DNA (p<0.05) were reduced, while the absolute number of peripheral lymphocytes (p<0.05), CD4+T cells and CD8+T cells(p<0.01)were increased. The rate of CD4+/CD8+ reduced to 0.98±0.05 from 1.28±0.08 (p<0.05). Conclusions CAPRI cells could reduce the load of hepatitis B virus and improve the liver function of chronic hepatitis B patients. CD8+T lymphocytes might play an important role in this process.
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