The paper Through the research on the expression levels of COX-2 and VEGF in the gastric low grade, high grade intraepithelial neoplasia and gastric carcinoma, to explore their difference between different precancerous lesions and their clinical significance,The Conclusion: The COX-2 expression were gradual y increased as the gastric mucosal lesions aggravated, while VEGF only began to show a certain level of expression in the high-grade intraepithelial neoplasia. It is supposed that, during the formation of gastric cancer, the expression of COX-2 may promote the expression of VEGF.