首页|两种IGRA检测方法诊断结核分枝杆菌潜伏感染的效能分析

两种IGRA检测方法诊断结核分枝杆菌潜伏感染的效能分析

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目的:比较γ-干扰素释放试验TB-IGRA和T-SPOT.TB检测结核分枝杆菌潜伏感染的效能和一致性。方法分别用TB-IGRA和T-SPOT.TB两种方法对18例志愿者、4例涂阳肺结核患者及1例非结核分枝杆菌感染者的外周血标本中特异性γ-干扰素的含量进行检测,进行平行比较分析。结果 TB-IGRA法和T-SPOT.TB法的敏感性、特异性、阳性预测值、阴性预测值均为100%,2种方法的Youden指数均为1,差异无统计学意义(P>0.05)。结论 TB-IGRA和T-SPOT.TB两种方法在诊断结核分枝杆菌潜伏感染方面有较好的效能和一致性,有临床应用价值,阴性结果在结核病鉴别诊断中有较重要的临床意义。
Objective To compare efficiency and consistency of type interferon gamma release assay on detecting mycobacterium tuberculosis latent infection by two different methods of TB-IGRA and T-SPOT.TB. Method Detect the specific IFN-γ of 18 volunteers, 4 patients with smear positive pulmonary tuberculosis, 1 case of non tuberculous mycobacterial infection for paral el comparative analysis by the two different methods. Results Sensitivity, specificity, positive predictive value, and negative predictive value of TB -IGRA and T-SPOT. TB were 100%, Youden index of the two methods was 1, indicating no statistical y significant (P > 0.05). Conclusion TB-IGRA and T-SPOT.TB have good consistency in the diagnosis of mycobacterium tuberculosis latent infection with a good clinical application value, and the negative result has a valuable significance in the differential diagnosis of tuberculosis.

Mycobacterium tuberculosisLatent infectionsInterferon gamma release assayTB-IGRAT-SPOT.TB

栗方芝、李娜娜、石亚萍、贺仁忠、陈玲

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贵州省遵义医学院附属医院呼吸二科 呼吸医学研究室 贵州遵义 563003

结核分枝杆菌 潜伏感染 γ-干扰素释放试验 TB-IGRA T-SPOT.TB

贵州省卫生厅科学技术基金贵州省结核病综合防治2011协同创新中心(培育)项目

gzkj2009-1-009

2014

中外健康文摘
中国中医药报社

中外健康文摘

影响因子:0.016
ISSN:1672-5085
年,卷(期):2014.(1)
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