Objective: The role of tumor budding(TB) and lymphovascular space invasion (LSI) scores on the prognosis of patients in colorectal cancer (CRC) surgery. Methods:Retrospective analysis of clinical and pathological data from 224 cases of CRC surgery patients, the scores of TB and LSI were evaluated using immunohistochemistry in CRC tissues, and analyzed the correlations between the scores of TB and LSI and clinicopathologic factors and patient survival. Results: The scores TB and LSI strongly correlated with the TNM stage, and difference was statistical y significant (p<0.001). Kaplan-Meier survival curves showed that scores of TB and LSI are inversely correlated with overal 5-year survival of patients with CRC (p<0.05 for both). Univariate and multivariate Cox regression analysis revealed that TB and LSI are an independent prognostic factor in CRC (p<0.05). Conclusion: The TB and LSI may serve as an independent prognostic factor and prematurely help to identify those patients with high risk advanced stage CRC.
Colorectal cancerTumor buddingLymphovascular space invasionprognosis
NETL
NSTL
万方数据
