objective: for the treatment of severe multiple trauma is damage control orthopedic clinical effect is analyzed, summed up the effective treatment methods. Selection methods: from April 2013 to January 2014, 51 patients with severe multiple trauma, the clinical treatment process of the damage control orthopedic treatment were analyzed retrospectively, to explore the clinical curative effect. Results: the 43 cases cured, the cure rate 84.3%, 8 cases of death, the mortality rate of 15.7%. Conclusion: damage control orthopedic treatment is particularly important for the treatment of patients with severe multiple trauma, patients can significantly decrease the mortality, curative effect, safe and reliable, worthy of clinical promotion.