Objective Exploring psychiatric risk factors for in-hospital stroke and possible mechanisms,Improve in-hospital stroke prevention awareness. Methods Retrospective analysis of 46 cases of in-hospital clinical data of stroke,Risk factors for in-hospital stroke and possible mechanisms for analysis. Results In-hospital stroke risk factors are age, smoking, high blood pressure, diabetes, high cholesterol, atrial fibril ation, infection, previous history of stroke, with emotion. Possible mechanisms for low perfusion and embolization of vascular wal lesion and brain, blood factors and other comprehensive. Conclusion Risk factors for in-hospital stroke range,Raise awareness and conducive to the prevention and treatment of stroke in the hospital.