摘要
目的：探讨黏液纤维肉瘤(myxofibrosarcoma，MFS)的临床病理学特征、免疫组化表达特点、鉴别诊断要点。方法收集3例MFS患者的临床及病理资料进行分析，复习相关文献。结果 MFS好发于老年男人，生长缓慢，多见于四肢、少见于躯干。结节状无痛性生长，肿块由梭形和星形的瘤细胞组成、分布于不规则多少一不等的黏液样物中，可见特征性细长弯曲的薄壁小血管、脂肪母细胞样瘤细胞；免疫组化vimentin、CD99瘤细胞3例均弥漫阳性，1例SMA、1例S-100局灶阳性。结论 MFS是一种伴有黏液样变的纤维母细胞性恶性肿瘤，多发生于老年人四肢皮下或深部肌层，临床表现为局部缓慢增大的无痛性肿块。容易误诊为软组织的良肿瘤或其它恶性肿瘤。
Abstract
Objective To investigate the mucus fibrosarcoma (myxofibrosarcoma, MFS) clinicopathological features, immunohistochemical expression features, differential diagnosis. Methods three cases the clinical and pathological data were analyzed MFS patients, review of the literature. Results MFS occurs in older men, slow growth, more common in the limbs, rare in the trunk. Painless nodular growth, tumor composed of spindle and stel ate tumor cells, irregularly distributed in an unequal number of mucus-like material, the visible characteristic elongated curved thin-wal ed smal blood vessels, fat-like mother cells immunohistochemical vimentin, CD99 tumor cells were diffusely positive three cases, one case of SMA, one cases focal S-100 positive tumor cells. Conclusions MFS is a conclusion with myxoid variant fibroblasts malignancy, occurs in the elderly or deep subcutaneous muscular limbs, clinical manifestations of local slowly increasing painless mass. Easily misdiagnosed as benign soft tissue tumors or other malignancies.
NETL
NSTL
万方数据