Objective: To investigate the effect of painless labor in clinic, and to guide clinical practice. Methods: From 2012 May to 2013 May in our hospital 106 cases of pregnant women, according to the time of admission were divided into experimental group and control group, 53 cases in each. The experimental group used epidural anesthesia for painless labor, the control group using the traditional natural childbirth, compared two groups of pregnant women on pain tolerance, labor time, postpartum bleeding, neonatal asphyxia rate. Results:The woman in pain tolerance than the control group, the difference was statistical y significant (P<0.05); the experimental group the first stage of labor time was (227.5±94.6) min, the time of the first stage as the control group (358.1±224.7) min, the experimental group was significantly shorter than that in the control group, the difference was statistical y significant (P<0.05); two groups in the amount of postpartum hemorrhage [experimental group (173±52.1) ml, the control group (169±49.6) ml], the rate of neonatal asphyxia [experimental group 3.8%, contrast group 5.7%], there was no statistical significance (P<0.05). Conclusion: Painless childbirth can reduce the pain degree of maternal, shorten the birth process, no adverse effects on mother and infant, clinical efficacy, is worthy of clinical application.