摘要
目的：观察不同剂量辛伐他汀治疗冠心病伴高血脂症的疗效及不良反应。方法将100例冠心病伴高血脂症患者随机分为3组：A组给予辛伐他汀20mg/d口服，B组给予辛伐他汀40mg/d口服，C组给予辛伐他汀80mg/d口服。3组分别在治疗前及治疗过程中定期检测血清胆固醇（TC）、低密度脂蛋白（LDL-C）等及安全性指标（TG、ALT、Cr、BUN及CK），比较不同剂量辛伐他汀的疗效及安全性。结果辛伐他汀80mg/d剂量降低TC、LDL-C的作用显著。结论辛伐他汀常规剂量（80mg）治疗冠心病伴高血脂症可取得较满意疗效。
Abstract
the efficacy and adverse reaction of different dose of simvastatin in treating coronary heart disease with hyperlipidemia.Methods 100 patients with coronary heart disease complicated withhyperlipemia were randomly divided into 3 groups: A group were given simvastatin 20mg/d oral, B group were given simvastatin 40mg/d oral, C group were given simvastatin 80mg/d oral. In the 3 groups before treatment and periodical y during the detection of serum cholesterol (TC), low density lipoprotein (LDL-C) index and safety (TG, ALT, CR, BUN and CK), to compare the efficacy and safety of different doses of simvastatin. Results simvastatin dose of 80mg/d reduced TC, LDL-C effect. Conclusion simvastatinconventional dose (80mg) in treating coronary heart disease withhyperlipidemia can obtain satisfactory effects.
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