objective: by comparing the sodium valproic acid and left braschig efficacy in the treatment of epilepsy in children, the curative effect of two drugs in treating children epilepsy, an in-depth understanding and ful y understanding, in order to achieve a good therapeutic effect. Methods: the author's hospital 01, 2013-01, 2014 children with epilepsy treated 70 cases randomly divided into two groups, each group of 35 cases, respectively, in left braschigand valproate treatment, observe and record the treatment effect, the data with statistics software SPSS 11.0 statistical analysis. Results: valproate in the treatment group, 4 cases were invalid, 21 cases with significant curative effect, 8 cases of complete control of disease, disease progression after treatment in 2 cases, total effective rate was 82.8%; In left braschigtreatment of children after treatment has no obvious effect in 3 patients, 23 cases with significant curative effect, 5 cases of complete control, 4 cases of disease progression after treatment, the total efficiency of 80%. The comparison of two groups of data no significant difference (P ﹥ 0.05). Conclusion: in the treatment of epilepsy in children, two kinds of drug efficacy difference between inorganic and are relative effective drug treatment of epilepsy in children, can be used in clinical treatment.