Objective: To evaluate thyroid disease TGAb TPOAb measured clinical value. Methods: Patients admitted to our hospital 68 cases of thyroid disease, giving al patients were measured by TGAb and TPOAb observed specific distribution of the measured values. Results: Serum TGAb, TPOAb positive in hyperthyroidism, goiter and hypothyroidism in relatively high, which hypothyroidism (hypothyroidism) ranked first in the positive, Conclusions: In various thyroid diseases, thyroid autoantibodies have positive there are some differences, but al types of thyroid disease TGAb, TPOAb also heterogeneous.