Objective To investigate the clinical symptoms of pulmonary thromboembolism (PTE) patients, thus to discuss the risk factors, clinical features, early diagnosis and treatment of PTE. Methods The clinical data of 44 patients hospitalized with PTE in Changsha Central Hospital were reviewed. Results PTE patients were associated with a number of risks including lower limbs venous thrombosis, the most frequent risk factor, and clinical symptoms and signs of PTE were usual y nonspecific. CT pulmonary angiography (CTPA) were helpful to the diagnosis. Early thrombolysis and anticoagulation therapy decreased the case fatality rate. Conclusions We should improve the recognition of PTE clinical features, which is important to get early and precise diagnosis and decrease the mortality and misdiagnosis. CTPA is the most reliable diagnosing method. Anticoagulation therapy is safe and effective, while the implantation of vena cava filter should be more restricted by the guidelines.