慢性丙肝患者血清HCV抗体与HCV RNA的相关性分析
The correlation analysis of HCV-Ab and HCV RNA in the chronic hepatitis C patients
韩亚男 1张锦伟 1许琳靖1
作者信息
- 1. 大连市第六人民医院检验科 辽宁大连 116031
- 折叠
摘要
目的：探讨慢性丙型肝炎患者外周血中HCV抗体与HCV RNA检测的相关性，为临床诊断提供依据。方法收集95例疑似慢性丙型肝炎患者血清，采用荧光定量逆转录聚合酶链反应(FQ-RT-PCR)进行丙型肝炎病毒检测及化学发光法检测HCV抗体。结果 HCV RNA阳性率为75.8%（72/95）；HCV抗体阳性率为71.6%（68/95），HCV抗体阳性率与HCV RNA含量呈正相关（r=0.941，P＜0.01）。结论 HCV抗体和HCVRNA的联合检测，对于丙型肝炎的临床诊断具有重要意义。
Abstract
Objective To study the correlation between HCV RNA quantitation and anti-HCV level in the chronic hepatitis C patients. Methods HCV RNA quantitation of 95 in the chronic hepatitis C patients were detected by auantitafed fluorescence quantitative reverse transcription polymerase chain reaction(FQ-RT-PCR) and anti-HCV level were detected by chemiluminescence immunoassay ELISA. Results There was positive correlation (r =0.883,P<0.01) between anti-HCV and HCV RNA in the chronic hepatitis C patients.Conclusion Simultaneously testing the quantitation of HCV RNA and Anti-HCV is helpful for the early diagnosis and treatment of Hepatitis C infenction.
关键词
HCV/RNA/实时荧光定量PCR/丙型肝炎病毒抗体Key words
Hepatitis C virus RNA/Fluorescence quantitative PCR/Antibody of HCV引用本文复制引用
出版年
2014
NETL
NSTL
万方数据