Objective: To investigate under the guidance of arthroscopic surgery to clean up the synovial joint homemade prescription treatment of knee synovitis effect. Methods: 68 cases of knee synovitis hospital patients were divided into two groups: a control group and the experimental group. The control group using a single synovial debridement; improvement rate after treatment were compared and the experimental group were treated with postoperative complications combined treatment of traditional Chinese medicine Self. Results: The improvement rate was significantly higher in the experimental group; incidence of postoperative complications in patients in the experimental group was significantly lower than the control group. Conclusion: Clean under the guidance of arthroscopic surgery synovial joint homemade prescription treatment of knee synovitis significant effect, can improve the condition improved rate and reduce complications.