Objective Analyze and discuss the clinical application of laryngeal mask. Method 158 patients with laryngeal mask to use, the application of retrospective analysis. Result The use of 158 cases of laryngeal mask airway in patients with laryngeal mask airway anesthesia, 152 cases with gastrointestinal operation open operation, laparoscopic cholecystectomy operation, operation anesthesia in children and so on; for emergency cardiopulmonary resuscitation in 6 cases; 3 of 31 cases with laryngeal mask, 4 laryngeal mask in 127 cases, 1 successful placement in 131 cases, second successful in 15 cases, third with the middle finger to guide placement in 6 cases, by laryngoscopy in 4 cases, 2 cases gave up; laryngeal mask placed for an average of 2.59 of H, 4 cases of leakage phenomenon. Conclusion Application of laryngeal mask in clinical anesthesia widely, can also be used for emergency difficult airway, the application of laryngeal mask has been greater than the tracheal intubation, and the application of laryngeal mask to the decline in the proportion of difficult intubation, laryngeal mask anesthesia management of clinical application to bring new choices and new ideas. Provides an easy way for airway management new.