Objective: to study the root canal treatment of dental pulp diseases and periapical disease clinical curative effect. Methods: our hospital between January 2012 and April 2013 were 46 patients (65 with tooth) dental pulp diseases and periapical disease treated with RCT, analyzes its root canal fil ing treatment. Results: in 65 of tooth fil ing treatment, just fil in 53, accounting for 81.5% of the proportion of the total, owe to fil eight, accounts for 12.3% of the proportion of the total, super five, accounts for 7.7% of the proportion of the total, root canal fil ing success rate was significantly higher molar, before (P < 0.05) difference was statistical y significant. Conclusion: root canal fil ing of dental pulp diseases and periapical disease treatment, the curative effect is distinct, the line of tooth root canal fil ing effect and the related, also associated with calcification degrees, root tube bending.