Objective To investigate the effect of nursing intervention on patients with chronic hepatitis B recurrence. Method By using a self-designed questionnaire, 50 cases of chronic hepatitis B relapse patients nursing intervention, including psychological adjustment, a person's diet, medication, self-care, self protection, daily training, regular examination and so on, recurrence rate were compared before and after intervention of difference, and the results of data analysis. Result After the intervention, patients were ful y aware of the importance of compliance, the recurrence rate was lower, the difference was statistical y significant (P < 0.01). Conclusion Nursing intervention can make patients maintain a pleasant mood, enhance confidence in the treatment of disease, improve the ability of self health care, can effectively prevent the recurrence of the disease.