0bjective To evaluate the clinical therapeutic effect and safeness of ibandronate and pamidronate in treating pain caused by bone metastasis.Methods 62 cases were randomly divided into ibandronate group and pamidronate group,31 cases of each.The ibandronate group was treated with ibandronate,while the pamidronate group was treated with. Both groups were treated for 2 to 6 cylces.Observed 2 group’s odynolysis effect,situations of bone reparation,activity ability and adverse reaction.Results On the 14th day of administration,the clinical benefit rate of ibandronate group was 87.1% higher than 64.5% of the pamidronate group,and the difference was statistical y significant(P<0.05). On the 56th day of administration.the clinical benefit rate of ibandronate group was 90.3% higher than 83.8% of the pamidronate group,and the difference was of no statistical significance(P>0.05).The main adverse reactions of 2 groups were fewer and weakness,and the severity had positive correlation with bone damage.Conclusion Ibandronate has good curative effects above pamidronate in treating pain caused by bone metastasis.Both of the two drugs has slight adverse reaction and good tolerance.Which are worth clinical popularizing and application.
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