Objective:To study the effect of Zhengqinfengtongning injection iontophoresis on temporomandibular disorders. Methods:Ninety patients of TMD were chosen and devided randomly into two groups. the experiment group:50 patients were treatmented by Zhengqinfengtongning injection iontophoresis ,another group was the contrasrive group:40 patients by Meloxicam .The mouth opening and pain-cured of two groups were observed. Results:After 3 courses of treatment, total effective rate of experimental group were 98.0%, and 82.5% in the control group, there were significant difference between two groups (P < 0.05). After observation of 6 months, the total effective rate of treatment group was 94.0%, control group 62.5%, two groups had significant difference (P < 0.05).