Objective explore and analyze Mahuangtang Ultramicro Pieces with traditional water-soluble and alcohol-soluble extract differences. Methods wave layer chromatography were identified Mahuangtang Ultramicro Pieces with traditional water-soluble and alcohol-soluble extract quantitative and for comparative analysis. Results Ultramicro soluble extract an average of 0.2295g, significantly better than the traditional slice of 0.1512g, both the ratio of 1.52, significant difference was statistical y significant (P <0.05); Ultramicro alcohol-soluble extract an average of 0.0497g, significantly better than the traditional slice of 0.039g, both the ratio of 1.27, significant difference was statistical y significant (P <0.05); Discuss on Chinese Herbal Medicine crushing treatment, not only not reduce the potency of herbs, but can improve the water solubility and quantitative pieces alcohol-soluble extract, and more significant than the record sheet swig efficacy, help improve clinical outcomes.