摘要
目的：对阿德福韦酯治疗慢性乙型肝炎的疗效进行调查分析。方法：选取2012年6月～2013年9月于本院就诊治疗的慢性乙肝炎患者93例，随机将其分为阿德福韦酯组（实验组）和拉米夫定组（对照组）两组，实验组患者口服阿德福韦酯而对照组患者口服拉米夫定，观察比较两组患者经治疗后取得的临床效果。结果：实验组患者较对照组相比，治疗12、24、48周后ALT、AST及HBV-DNA含量变化更为显著，差异有统计学上意义（P<0.05）；实验组经治疗后HBV-DNA、HBeAg/anti-HBe转换情况明显优于对照组的，差异有统计学意义（P<0.05）。结论：阿德福韦酯治疗慢性乙型肝炎，效果显著，是值得推广应用的治疗药物。
Abstract
Objective:To investigate and analyze the clinical efficacy of adefovir in the treatment of chronic hepatitis B(CHB).Methods:93 CHB patients in our hospital from June 2012 to September 2013 were randomly divided into adefovir group (experimental group) and lamivudine group (control group),adefovir and lamivudine were given in two groups respectively,efficacy of two groups after treatment were compared.Results:Changes of ALT,AST and HBV-DNA after 12,24,48 weeks of treatment in experimental group were more significant than control group,difference was statistical y significant (p<0.05),transfer situation of HBV-DNA,HBeAg/anti-HBe of experimental group was better than control group,difference was statistical y significant (p<0.05),Conclusion:Efficacy of adefovir in the treatment of CHB is significant,which deserves to be promoted inclinic.
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