objective To study efficacy analysis and adverse reactions of alteplase treating acute myocardial infarction. Method Col ecting 96 cases of patients with acute myocardial infarction of our hospital from March 2010 to March 2013. We divide them into two groups randomly, and name them as the experimental group and control group,and each group has 48 people. Al patients were started on intravenous thrombolytic treatment within 30min. Experimental group received alteplase treatment. The alteplase 50 mg was dissolved in 50ml of special solvents, then intravenous injection 8mg. The remaining 42mg infusion is completed within 90min. The patients were given a certain amount of low molecular weight heparin administered subcutaneously twice daily before and after thrombolysis. The control group received urokinase treatment. 150 000 U of urokinase was dissolved in 100ml of saline and was dropped in 30min,then give patients APTT monitor. two groups were performed 8 days under the premise of the no serious adverse reactions. Result Compared with the control group, the experimental group have slightly higher number of patients with symptoms of chest pain and coronary recanalization ,but the difference was not statistical y significant(P>0.05). The number of heart disorders, heart failure, post-infarction angina in the experimental group was significantly lower than the control group (P <0.05). Conclusion The clinical efficacy of alteplase is considerable to urokinase, but adverse reactions are less than urokinase.
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