In recent years, the clinical application of antibiotic drugs has become the most important and widely used class of drugs, while the prevention and treatment of infectious diseases, antimicrobial drug abuse phenomenon is also more serious, especial y in hospital, mainly in inappropriate choice of antibacterial drugs, long-term or improper combination of antimicrobial drugs, improper antimicrobial drug compatibility, etc. Therefore, how to regulate the rational use of antimicrobial drugs has become the primary hospital management difficulties and focus today. In this article, I wil combine their years of accumulated experience in pharmaceutical management, and actively explore the primary hospital antibiotic medicines management approach that comprehensive measures only through administrative intervention and dynamic combination of scientific guidance in order to effectively improve the rational use of antibiotic drugs.