Objective To explore the application of PDCA cycle to reduce the effect of errors of drug dispensing. Methods PDCA circulation method for the management of drug dispensing errors, and analyze the contrast ratio before and after management errors in dispensing drugs appeared, indicating that PDCA cycle to reduce the effect of errors of drug dispensing. Results after the application of PDCA circulation method to supervise and control the drug dispensing, before carrying out drug dispensing error ratio 82.40%, dropped to 1.40%after the effective date of contrast error rate before and after the analysis of statistics significance (x2 = 16.12, p < 0.05). Conclusion using PDCA cycle to reduce drug dispensing error, avoid medical disputes, improve patient satisfaction is of great significance.