摘要
目的：：探讨胃蛋白酶原Ⅰ（P GⅠ）和胃蛋白酶原Ⅱ（P GⅡ）检测对胃溃疡患者的筛查作用。方法：选取2013年1月-10月在青浦中心医院的体检者2052例，胃溃疡患者120例，分别检测血清P GⅠ和P GⅡ，并计算P GⅠ/P GⅡ比值，统计学分析三个指标在体检者与胃溃疡患者之间的差异。结果：胃溃疡患者血清PGⅠ、PGⅡ和PGⅠ/PGⅡ分别为316.7±129.2ng/ml、40.2±30.1ng/ml 和12.0±4.9，三者均显著高于体检人群（156.0±63.8ng/ml，15.9±11.1ng/ml 和9.7±4.3）（P<0.05）。如果以体检人群95%的可信区间设定正常参考值，则PGⅠ、PGⅡ和PGⅠ/PGⅡ的参考值分别为<270.9ng/ml、<37.8n g/m l和<14.4，它们对胃溃疡的阳性预期值分别为61.7%、55.8%和13.3%。结论：胃溃疡患者血清P GⅠ和P GⅡ水平均显著高于体检者，因此它们可能用于大规模人群胃溃疡的筛查。
Abstract
Objective: To investigate the screening effect of pepsinogenⅠ (PGⅠ) and epsinogenⅡ(PGⅡ) detection on gastric ulcer patients. Methods: 2052 physical examination population and 120 gastric ulcer patients were selected for PGⅠand PGⅡ detection in XXX hospital,from January 2011 to October 2011. Results: Serum PGⅠ, PGⅡ, and PGⅠ/PGⅡ in physical examination population were 316.7±129.2ng/ml, 40.2±30.1ng/ml, and 12.0±4.9, respectively. Each was significantly higher than those in gastric ulcer patients (156.0±63.8ng/ml, 5.9±11.1ng/ml, and 9.7±4.3,respectively.)(P<0.05). If PGⅠ<270.9 ng/ml as a reference, Positive expectations to gastric ulcer was 61.7%; PGⅡ<37.8ng/ml as a reference, Positive expectations to gastric ulcer was 55.8%; PGⅠ/PGⅡ<14.4 as a reference, Positive expectations to gastric ulcer was 13.3%. Conclusion: Serum PGⅠ and PGⅡ in gastric ulcers was significantly higher than those in physical examination population. Therefore, they may be useful in screening of gastric ulcer patients in large populations.
NETL
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万方数据